just because 2k1 runs fine under vista for mark doesn't mean it's going to run for you. i'd strongly urge you to run the vista upgrade advisor found here:
http://www.microsoft.com/windows/products/windowsvista/default.mspx
if'n you're purchasing a honkin' pc, you SHOULD be good to go. but there's something about an ounce of prevention thing. (8
edit: it just hit me you'll probably be buying a new pc with vista on it. sorry, i've just never had a new pc with an operating system already on it. new territory for me. but if'n i do ever buy a new pc outta the box, the first thing i would do is reformat/reinstall the os.